People with epilepsy (PWE) carry a heavy burden of psychiatric disorders including depression, anxiety, psychotic disorders, ADHD, and functional disorders. These psychiatric disorders may produce worse outcomes including reduced seizure remission rates and increased rates of hospitalization. Current studies look at the prevalence of psychiatric comorbidities in epilepsy or have explored singular outcome measures such as hospitalization or remission status.

Our study delineates the connection between specific psychiatric comorbidities and outcomes in PWE. Our study amalgamates documented psychiatric comorbidities and evaluates associations with multiple outcome measures including seizure remission status, disability, death, and cognitive impairment.

Clinical question: ‘What is the association between specific psychiatric comorbidities and clinical outcomes and prognosis in people with epilepsy?’